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Asterios Aidonis, Anthropologist, PhD candidate on Biological Anthropology, Department of History and Ethnology, Democritus University of Thrace is being interviewed by Apostolos Verikios, a second-year medical student of the School of Medicine, Aristotle University of Thessaloniki. This fourth part of the interview discusses the methods used for performing trephinations in antiquity and the reasons associated with this methods. Furthermore, the type of practitioners who performed them over time are presented, showing differentiations occuring along with the transformation of medicine.