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Asterios Aidonis, Anthropologist, PhD candidate on Biological Anthropology, Department of History and Ethnology, Democritus University of Thrace is being interviewed by Apostolos Verikios, a second-year medical student of the School of Medicine, Aristotle University of Thessaloniki. This first part of the interview focuses on the clarification of the historical timeline of trephinations for therapeutic reasons. The first findings of trephinated skulls in the world are presented while there is attempt to clarify the reasons for practising trephination.