The text is a commentary to the Hippocratic book On Regimen in Acute Diseases written in 400 B.C.E
and commented by Galen. The manuscript has been printed by Aldine between 1525-1526 and copied by Kallistos in Rome under the mastery of the Cardinal Bessarion who had been working to the complete the works of Galen. Kallistos has been coping a manuscript of XIIth C. elaborated by Ioannikos, a copyist located in Constantinople. The manuscript has been transferred in Italy by the Ambassador Burgundio from Pisa. Kallistos born in the Byzantine Empire in the early XVth C. and left Constantinople in exile to commute to Padua around the 1441, and successively in Bologna to work under Cardinal Bessarion. In Bologna he thought philosophy at the University of Bologna, a course of Moral Philosophy about the Ethics of Aristotle, but as a philologist he translated several manuscripts from Greek and Latin. The Manuscript is interrupted on the 12th line of the book III of On Regimen in Acute Diseases at the discussion about the therapeutic effect of wine. The manuscript has not titles related to the first three books and its copy is situated between 1468 and 1471. The manuscript presents several contaminations, form other Hippocratic works and other manuscripts versions on the same work written between the XIIth C and the XVth in Europe.